A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen.
نویسندگان
چکیده
BACKGROUND There have been conflicting data in literature about the value of Phyllanthus amarus in treating hepatitis B virus-related disorders. AIM To evaluate the role of Phyllanthus amarus in eradication of the virus in hepatitis B carriers. METHODS Phyllanthus amarus was administered to 30 asymptomatic carriers of hepatitis B surface antigen (HBsAg) in a dosage of 250 to 500 mg thrice daily for 4 to 8 weeks. RESULTS None of the 30 subjects cleared HBsAg. Phyllanthus amarus was well tolerated, with no clinical side effects or changes in the organ profiles for safety evaluation. CONCLUSION Phyllanthus amarus is not effective in clearing HBsAg in asymptomatic carriers of the antigen.
منابع مشابه
Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus.
In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus amarus for 30 days. 22 of 37 (59%) treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. Some subjects have been followed for up to 9 months. In no case has the surface antig...
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ورودعنوان ژورنال:
- Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
دوره 13 1 شماره
صفحات -
تاریخ انتشار 1994